Endocrine Abstracts

Parathormone (PTH) is the marker for bone remodelling in chronic renal failure. The biologically active PTH 1–84 intact molecule (PTHibio) is supposed to better correlate with the degree of remodelling than PTH-intact (PTHi) which also binds to the 1–34 fragment. Our aim was to examine the PTH levels in dialysed patients with these two methods, considering also the total 25-hydroxi-vitamin-D (t-25OHD) levels.Methods: patients (age 63±15 ye...

Sufficient vitamin D supply is essential for general health. The total 25-hydoxy-vitamin-D (t-25OHD) level refers to the vitamin D supply and can be measured with various methods. Since these methods are not independent of the serum matrix, differences can be obtained among vitamin D levels measured with different methods. Our aim was to study the vitamin D in healthy blood donors, taking also into consideration the use of oral contraceptives (OC).Method...

The majority of circulating total 25-hydroxi-D-vitamin (t-25OHD) is bound to proteins – 90% to vitamin D binding protein (DBP) belonging to the alfa-2-globulin (a-2gl) fraction and 10% to albumin (ALB). Nowadays the t-25OHD level is the most accepted marker of vitamin D supply in physiological states. Our aim was to investigate the t-25OHD concentration in clinical conditions with low albumin levels.Methods: Seventy-three patients (39 men, 34 women;...

The incidence of macroprolactinemia decreased notably because of wide use of prolactin (PRL) assays measuring macroprolactin at a lower rate. However, in case of high PRL levels, measurement of monomeric PRL (mPRL) levels after polyethylene glycol (PEG) treatment is still required. Our aim was to determine – by the use of a second generation PRL assay – how total PRL (tPRL) levels in native sera of healthy blood donors change after PEG treatment. In women, the use of...

Aldosterone/renin ratio (ARR) is obtained by measurements of plasma aldosterone (ALD) and either plasma renin activity (PRA) or direct renin concentration (DRC). The various gestogen components (desogestrel, DSG; gestoden, GD; drospirenon, DRSP) of the frequently used oral contraceptives (OC) can influence the ARRs differently. Aim of the study was to analyze the effect of OCs with different gestogens and low-dose estradiol component on ARRs (ALD/PRA versus ALD/DRC).<p cla...

Plasma total testosterone (TT) does not provide reliable information about the biological active testosterone, since a large proportion of this hormone is bound to either specific (sex hormone binding globulin, SHBG) or non-specific binding proteins (albumin). Free testosterone (fT) represents not more than 0.7–2.2% of TT while bioavailable testosterone (BA-T) in females is about 15–48% of the TT. The aim was to investigate the analytical and clinical correlations am...

Introduction: Human tear is rich in cytokines, i.e. in healthy individuals it exhibits a higher ratio of cytokines to total proteins than that in the serum of the same individual. EOP related to Graves–Basedow disease is thought to develop due to elevation of serum cytokine levels and to an altered cytokine response of the intra- and periorbital tissues. In our present study we focused on the measurement of IL6, IL8 and TNF-α, the relative amount of a lipocalin-type ...

Background: The most reliable biochemical markers in the follow-up of medullary thyroid carcinoma (MTC) are serum calcitonin (CAL) and carcinoembrional antigen (CEA).Case: A 82 years male presented with rapidly growing neck tumour in April 2008. The patient underwent total thyroidectomy with lymph node dissection (June 2008). The pathology revealed MTC localized only in the left lobe (pT3NoMx), the immunohistology showed CAL-, synaptophysin, chromogranin...

Familial isolated pituitary adenoma (FIPA) occurs if two or more members of a family develop pituitary adenoma with no features of multiple endocrine neoplasia type 1 or Carney complex. FIPA is an autosomal dominant disease with incomplete penetrance. FIPA families can be divided into two distinct groups based on genetic and phenotypic features. In 20% of FIPA families mutations have been identified in the aryl hydrocarbon receptor interacting protein (AIP) gene. The AIP-posit...